Allergen-specific IgE (Components) Test Kit

Allergic diseases are conditions in which a patient inhales or ingests substances containing allergenic components (called allergens or allergens, allergen) that trigger the body’s B cells to produce excessive immunoglobulin E (IgE). When IgE antibodies are re-exposed to allergens in vivo, they cross-link with allergens and bind to the higher affinity receptor FcεRI on the surface of mast cells and basophils, resulting in FcεRI accumulation and mast cell and basophil activation. During activation, mast cells degranulate and release histamine, an inflammatory mediator stored in cytoplasmic granules, and leukotrienes, immunoreactive prostaglandins, cytokines and chemokines such as IL-4 and IL-5 synthesized through arachidonic acid pathway, triggering disease symptoms of allergic reactions (or allergic reactions), such as allergic asthma, hay fever, urticaria, allergic rhinitis, eczema, allergic dermatitis, conjunctivitis and gastrointestinal dysfunction. The determination of corresponding allergen-specific IgE antibodies in serum can be used to assist in the diagnosis of substances causing allergic reactions in clinical practice and select the appropriate immunotherapy regimen for patients.

The assay of allergen component is a new method for the diagnosis of allergic diseases, also based on the detection of specific IgE. Unlike crude allergen extracts used in traditional diagnostic methods, component elucidation diagnosis uses purified natural/recombinant monomer allergy to originally identify specific molecules causing allergy, making the diagnosis of allergic diseases more accurate. It can accurately diagnose which types of allergen proteins the patient is allergic to and how allergic he is, thus providing a basis for further individualized treatment. The use of this allergenic protein fraction as a desensitization therapy reagent avoids the side effects that may result from non-allergenic protein fractions or non-protein components of allergen extracts. Allergen component detection can identify truly sensitized protein components in allergens, solve the allergen-specific diagnostic problems caused by cross-reaction, and ensure the accuracy and effectiveness of allergic disease detection. This method can precisely understand the situation of allergen cross-reaction and predict other possible allergens.