Autoimmune Diseases（Chemiluminescense Immunoassay）

Our company produces human recombinant antigens for in vitro diagnosis of autoimmune diseases. Baculovirus/insect cell expression systems are commonly used to express large-scale foreign proteins due to their high expression levels and post-translational modification capabilities. The human recombinant protein expressed by Baculovirus/insect cells has high biological activity, and its antigenicity and immunogenicity are similar to the natural human protein, while the natural protein obtained from animals is different from the natural human protein. Due to the limited resources and different sources of natural proteins, the purity of naturally purified antigens is low and inconsistent between batches. The recombinant antigen produced by our company has high purity and ensures the consistency between batches. To date, we provide high-quality antigens for the following items, Anti-Nuclear Antibody, Autoimmune Hepatitis. ANCA-Related Vasculitis, Type I Diabetes, Infertility, Antiphospholipid Syndrome, Membranous Nephropathy, Autoimmune Encephalitis, Interstitial Pneumonia, Rheumatoid Arthritis, Central Nervous System Demyelinating Diseases, Related Antibodies

Performance
The autoimmune antigens are purified by affinity chromatography and/or HPLC. Protein identity and amino acid composition are verified by mass spectrometry and by amino acid analysis. Immune reactivity is validated by monoclonal antibody binding. Purified proteins are also validated for IgG antibody binding.

Applications:
In vitro studies of T-cell function and antigen presentation
Innate Immunity
Antibody detection,
Structural studies and biologic assays