Inflammatory Bowel Disease(IBD) Test Kit

Inflammatory bowel disease (IBD) is a rare clinical disease with unknown etiology. It belongs to non-specific intestinal inflammation, including Crohn disease (CD) and ulcerative colitis (UC). CD was discovered by Burrill Crohn in 1932 and it is an inflammatory disorder of the gut of unknown cause that can occur anywhere in the gastrointestinal tract, but with a predilection for the terminal ileum and right colon. UC is quite common in western countries. With the improvement of national living standards, the incidence rate of inflammatory bowel disease has increased significantly in recent years. Recent studies have reported that ASCA is a serum reactive antibody to Anti-Saccharomyces cerevisiae wall mannan, including both IgG and IgA. ASCA is a serological marker for most patients with CD and a recent study found that the presence of both ASCA IgG and ASCA IgA has 100% specificity for CD. Therefore, ASCA detection may be valuable in identifying CD andUC in some patients.

With the involvement of environmental factors and the participation of intestinal flora, the susceptible population initiates intestinal immune response, leading to intestinal mucosal barrier injury, inflammatory hyperplasia and other pathological changes. IBD include ulcerative colitis (UC) and Crohn disease (CD). Nearly 5%-15% of IBD patients are difficult to identify, termed inflammatory bowel disease unclassified (IBDU) and indeterminate colitis (IC). IBD is quite common in western countries. With the improvement of national living standards, the incidence rate of inflammatory bowel disease in China has increased significantly in recent years. Anti-intestinal goblet epithelial cell antibody (GAB) are currently considered as specific serum antibodies for UC and are suitable for early screening. High titres of anti-intestinal goblet cell antibody are predominantly found in ulcerative colitis and some patients with CD. And in close relatives of patients with inflammatory bowel disease, predicting a predisposition to inflammatory bowel disease. Detection of anti-intestinal goblet cell antibody in close relatives of patients with IBD predicts predisposition to IBD.