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Lipid Metabolism Chemiluminescense Immunoassay Kit

short description:

Lipid metabolism refers to the majority of the body’s intake of fat through bile emulsification into small particles, pancreatic and small intestinal endocrine lipase hydrolysis of fatty acids in fat into free fatty acids and glycerol monoesters. The detection of lipid items has high value and significance for the auxiliary diagnosis and differential diagnosis of coronary heart disease, atherosclerosis and other diseases.


Product Detail

Product Tags

Clinical Chemistry Solution

Series

Product Name

Abbr

Lipid Metabolism

Apolipoprotein A1

Apo A1

Apolipoprotein B

Apo B

Apolipoprotein E

Apo E

Lipoprotein A

LP(a)

Triglyceride

TG

Total Cholesterol

TC

High Density Lipoprotein Cholesterol

HDL-C

Low Density Lipoprotein Cholesterol

LDL-C

small dense Low Density Lipoprotein Cholesterol

sd LDL-C

Lipid metabolism refers to the majority of the body’s intake of fat through bile emulsification into small particles, pancreatic and small intestinal endocrine lipase hydrolysis of fatty acids in fat into free fatty acids and glycerol monoesters. The hydrolyzed small molecules, such as glycerol, short and medium chain fatty acids, are absorbed by the small intestine into the bloodstream. After absorption of monolipids and long-chain fatty acids, triglycerides are first resynthesized in small intestinal cells and formed with phospholipids, cholesterol, and proteins into chylomicrons, which pass through the lymphatic system into the bloodstream.

ApoA1 is the main structural protein of high-density lipoprotein (HDL), which can remove cholesterol from cells and prevent atherosclerosis. Therefore, the determination of ApoA1 combined with the detection of other lipid items (cholesterol, triglyceride, apolipoprotein B, etc.) has auxiliary diagnostic value for screening coronary heart disease.

ApoB is the major structural protein of low-density lipoprotein (LDL), which transports cholesterol into cells and is therefore associated with atherosclerotic plaque formation. Therefore, the determination of ApoB combined with the detection of other lipid items (cholesterol, triglyceride, apolipoprotein B, etc.) has auxiliary diagnostic value for screening the risk of coronary heart disease and lipoprotein metabolism disorders.

Lp(a) is a dimer composed of LDL molecules bound to Apo(A), which has an atherogenic effect. Lp(a) is a risk factor for coronary heart disease independent of other lipid parameters, and has high predictive value for coronary heart disease risk, especially when Lp(A) and LDL concentration are increased simultaneously. Therefore, the detection of Lp(A) combined with the detection of other lipid items has high value and significance for the auxiliary diagnosis and differential diagnosis of coronary heart disease, atherosclerosis and other diseases.

Triglycerides are esters formed by three hydroxyl groups in glycerol and three long-chain fatty acids. It’s partly made in the liver and partly from digested food. The determination of triglyceride is used for the diagnosis and efficacy monitoring of diabetes, nephropathy, liver obstruction, lipid metabolism disorder and various endocrine diseases. It is of great significance and value for the auxiliary diagnosis and differential diagnosis of coronary heart disease and familial lipoproteinemia.

Cholesterol synthesis is ubiquitous in the body and is a major component of cell membranes and lipoproteins. The determination of cholesterol is of great significance and value in the screening of atherosclerosis risk, monitoring of lipid metabolism disorders, therapeutic effect monitoring, auxiliary diagnosis and differential diagnosis of malnutrition, liver disease and other metabolic diseases.

High-density lipoprotein (HDL) is responsible for the reverse transport of cholesterol from peripheral cells into the liver. In the liver, cholesterol is converted to bile acids, which travel through the biliary tract to the intestine. Epidemiological and clinical studies have proved that HDL-C is negatively correlated with coronary heart disease, so it is very important to monitor serum HDL-C concentration clinically. Elevated HDL-C helps protect against coronary heart disease, while lower HDL-C concentrations, especially when associated with elevated triglyceride concentrations, increase the risk of cardiovascular disease. Cholesterol is synthesized by somatic cells and absorbed from food, transported by lipoproteins in the serum.

Low-density lipoprotein (LDL) is involved in transporting cholesterol to peripheral cells, and LDL-C plays an important role in the development and progression of atherosclerosis and coronary atherosclerosis. Therefore, the detection of LDL-C combined with the detection of other lipid items has high value and significance for the auxiliary diagnosis and differential diagnosis of coronary heart disease, atherosclerosis and other diseases.


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