Pemphigus Chemiluminescense Immunoassay Kit

Pemphigus is a group of autoimmune bullous skin lesions involving skin and mucous membrane. Under a variety of pathogenic factors and the body produces specific antibodies directed against the surface desmosomes of keratinocytes, resulting in the release of acanthocytes. According to clinical manifestations, pemphigus can be divided into four types: normal, proliferative, defoliated and erythematous. Studies have confirmed that desmoglein (Dsg) plays a key role in the pathogenesis of pemphigus. Dsg 1 and Dsg3 IgG antibody are confirmed to be the major pathogenic antibodies. The incidence rate of pempgigusvulgaris (PV) is the highest and the most severe subtype in pemphigus. The occurrence of anti Dsgl antibody indicates that besides the oral presentation, it also involves lesions of skin and other mucosa. PV usually starts in the oral cavity (50% to 70% cases) and occurs before other lesions. It can be the only clinical manifestation of this disease. Therefore, the oral surgeons play an important role in the early detection and early diagnosis of PV. The presence of anti Dsg1 antibody and anti Dsg3 antibody in serum of pemphigus patients can be used to determine its clinical phenotype. The titer levels of the two antibodies and their subtypes can be used to determine the condition and activity. These have important guiding significances for the diagnosis and treatments of pemphigus.

Paraneoplastic pemphigus (PNP) is an acquired bullous disorder associated with autoimmunity. Clinical presentation presented with multiorgan damage. The most common symptoms are refractory stomatitis, erosions, ulcers, haemorrhage of mucosa of mouth and lips. The pathogenesis of PNP is not well defined. IP confirmed that autoantibodies in patient sera recognize a variety of epidermal intracytoplasmic desmoplakin (plakin family) antigens. Studies confirmed that anti Dsg3 antibody plays a key role in acantholysis and blister formation of PNPs in passive transfer assays.

Bullous pemphigoid (BP) is an autoimmune bullous skin disease, which is commonly seen in the elderly over 60 years old. The main pathogenic antigen of BP is cutaneous half desmosomes and its main components are bullous pemphigoid antigen (BPAGl, BP230) and bullous pemphigoid antigen 2 (BPAG2, BPl80, cartilage type collagen). The detection of anti BPl80 specific antibody has high sensitivity and specificity, which can be used as an important index for guiding clinical practice.