Liver disease is a general term for all diseases that occur in the liver. Including infectious diseases, oncologic diseases, vascular diseases, metabolic diseases, toxic diseases, autoimmune diseases, hereditary diseases, such as intrahepatic cholangiolithiasis. The determination of α -1-Antitryp Sin, ceruloplasmin, complement, immunoglobulin, transferrin and prealbumin has certain significance in the diagnosis of some diseases of liver.